Description

Assignment: 1)implement a python function that calculates the concentrations of the metabolites in steady state depending on the parameter values. 2) To make the substrate inhibition of the HK-PFK system less cooperative, set n H = 1. To which value must the parameter kHK − PFK be changed in order to maintain the same steady state as with the standard parameters? 3) Vary the rate constant of the ATP consumption k ATPase systematically and plot the stationary ATP concentration once as a function of the parameter itself and once as a function of the ATP consumption rate vATPase for both model variants. 4) Plot the steady state glycolytic flow (J = v HK − PFK) as a function of the parameter k ATPase. 5) Calculate the flux control coefficient for the glycolytic flow J = v HK − PFK and the concentration control coefficient for the metabolites ATP and P23G for both model variants. Interpret the results.